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These results were supported by another study that found that patients given AGE demonstrated a significant slowing of the accumulation of coronary artery calcification.

Several investigators have found a significant and direct correlation between amount of coronary calcium and amount of atherosclerosis [15-18].We sought to evaluate the ability of AGE to inhibit coronary artery calcium (CAC).Methods: Four placebo-controlled, double-blind, randomized studies were pooled to determine whether the atherosclerotic plaque burden detected by CAC will change at a different rate under the influence of AGE as compared to placebo.Progression of calcified lesions in the wall of the coronary artery has been investigated as an active process of atherosclerosis, dependent upon multiple variables [21].Since AGE has been shown to have several potential anti-atherosclerotic properties, including stimulation of microcirculation in peripheral arteries, it was chosen as the agent of study to evaluate its ability to inhibit progression of coronary atherosclerosis.A two-sample median test was used to compare medians of CAC progression between the garlic- and placebo-treated groups.

CAC progression was also categorized into three groups (20%) prior to adjustment for age and gender.

Garlic and garlic extracts have been postulated to impart cardiovascular benefits through multiple mechanisms.

AGE has been shown to lower low-density lipoproteins (LDLs) [3] reduce the progression of coronary atherosclerosis, improve vascular function, and have a favorable effect on oxidative biomarkers [4-6].

Received date: September 10, 2015; Accepted date: September 21, 2015; Published date: October 05, 2015 Citation: Hom C, Luo Y, Budoff MJ (2015) The Effects of Aged Garlic Extract on Coronary Artery Calcification Progression. Since AGE has been shown to have several potential anti-atherosclerotic properties, including stimulation of microcirculation in peripheral arteries, it was chosen as the agent of study to evaluate its ability to inhibit progression of coronary atherosclerosis.

Visit for more related articles at Journal of Nutrition & Food Sciences Background: Aged Garlic Extract (AGE) has been shown to lower LDL, reduce the progression of coronary atherosclerosis, improve vascular function, and have a favorable effect on oxidative biomarkers.

AGE helps to modulate cardiovascular risk factors by lowering blood pressure, inhibiting platelet aggregation and adhesion, lowering cholesterol, preventing LDL oxidation and smoking-induced oxidative damage [7,11,12].